WebDec 12, 2011 · The most recently reported reaction, developed by Princeton University chemists David W. C. MacMillan and David A. Nagib, uses a mild method to generate a … In coupling reactions between aromatic compounds and metal-trifluoromethyl complexes the metal is usually copper, Pd and Ni are less prominent. The reactions are stoichiometric or catalytic. In the McLoughlin-Thrower reaction (1962) iodobenzene reacts with trifluoroiodomethane (CF3I) and copper powder in dimethylformamide at 150 °C to trifluoromethylbenzene. The intermediate in this reaction type is a perfluoromethyl-metal complex.
Divergent Radical Cyclization and Hydroaminoalkylation of N ...
WebAug 30, 2011 · The unique and orthogonal reactivity of the trifluoromethyl radical relative to aryl radicals has also been investigated on both a complex natural product and a pharmaceutical agent. Finally, preliminary data suggest that the regioselectivity of C-H trifluoromethylation can be fine-tuned simply by judicious solvent choice. WebJun 25, 2010 · A palladium-catalyzed trifluoromethylation of aryl halides has the potential to overcome these limitations: The use of a trifluoromethyl source as a transmetalating … the main character is the villain chapter 39
Radical Trifluoromethylation using Langlois Reagent
http://www.beijingyuji.com/english/innovation/science-are-around/400.html WebDec 3, 2010 · State-of-the-art ab initio electronic structure methods have been employed to pinpoint the electron affinity of the trifluoromethyl radical, EA(CF 3).The theoretical techniques entailed restricted and unrestricted Hartree-Fock reference wavefunctions, contemporary density functional schemes, second-order Moller-Plesset perturbation … WebThe present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base. the main character is the villain chapter 17