Sumo ythdf2
Web11 Apr 2024 · Bladder cancer (BLCA) is the most common form of urothelial cancer worldwide. It ranks first in the incidence of genitourinary cancer in China, while in the West, its incidence ranks second to prostate cancer [1,2].The incidence rate of BLCA increases with age and reaches a peak at 50–70 years old [3,4].The etiology of BLCA includes a … Web8 Apr 2024 · The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay during cell cycle. Depletion of YTHDF2 in HeLa cells leads to the delay of …
Sumo ythdf2
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WebYTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation Grenov A., Hezroni H., Lasman L., Hanna J. H. & Shulman Z. Cell reports (Cambridge) 2024 Go to publication Web18 Nov 2024 · Mechanistically, YTHDF2 processed the decay of m 6 A-containing interleukin 11 (IL11) and serpin family E member 2 (SERPINE2) mRNAs, which were responsible for …
Web18 Mar 2024 · YTHDF2 was modified by SUMO1 with a size of Mr ∼95–100 kDa (the expected normal size of YTHDF2 is 70 kDa), which is YTHDF2 covalently conjugated with … Web13 Jun 2024 · The currently confirmed readers include YTH domain proteins (YTHDF1, YTHDF2, YTHDF3, YTHDC1 and YTHDC2) and HNRNP family proteins. 12 Among them, YTH domain family 2 (YTHDF2) is the most effective m 6 A reader, exhibiting a series of biological processes involved in cancer carcinogenesis. 14 As a main cytoplasm m 6 A …
Web10 Apr 2024 · YTHDF2 preferentially bound to m 6 A-methylated CCND1 mRNA and diminished its expression, partially arresting MCE and inhibiting adipogenesis . Secondly, m 6 A reader YTHDF2 can modulate JAK/STAT signaling pathway. Wu et al. observed that there was a negative relationship between the expression of JAK2 mRNA and m 6 A level … WebYTHDF2 deficiency in TAMs suppressed tumor growth by reprogramming TAMs toward an antitumoral phenotype and increasing their antigen cross-presentation ability, which in …
WebYTHDF2 was transferred into SW1990 and PaTu8988 cells, and then YTHDF2 overexpression was examined at mRNA by real-time PCR (Fig. S1A). Unexpectedly, no significant changes in the level of protein were observed in YTHDF2 overexpres-sion group (Fig. S1B). Subsequently, we identified plasmids Vector and Flag-YTHDF2 in H293T cell, …
WebThis gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in … fifa 21 pc download mediafireWeb3 Mar 2024 · National Center for Biotechnology Information griffin logistics houstonWeb5 Apr 2024 · YT521-B homology domain family member 2 (YTHDF2) is an N6-methyladenosine (m6A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor … griffin logistics limitedWeb15 Feb 2024 · ythdf2的sumo化修饰主要发生在第571位赖氨酸残基上。 通过生化、细胞学实验、MeRIP-Seq和RNA-Seq和小分子抑制剂等多种新技术方法，证明了YTHDF2的SUMO … fifa 21 pc key freeWebYTH domain family, member 2 [Source:HGNC Symbol;Acc: 31675] Gene Synonyms HGRG8, NY-REN-2 Location Chromosome 1: 29,063,271-29,096,287 forward strand. About this transcript This transcript has 5 exons, is annotated with 7 domains and features, is associated with 10632 variant alleles and maps to 405 oligo probes. Gene fifa 21 pc download free crackedWeb9 Nov 2024 · One key function of YTHDF2 is to bind to the m6A chemical modification on mRNA and promote degradation. Our work demonstrating that YTHDF2 downregulates the activity of pro-inflammatory genes, may establish a paradigm whereby m6A mRNA modification regulates inflammatory pathways in blood and also other tissue stem cells. fifa 21 pc game torrentWeb16 Feb 2024 · YTH domain of YTHDF2 was a globular fold with four-stranded β-sheets (β1-β4), four α helices (α1-α4) and flanking regions on two sides. Besides, residues K416 and R527 of the above C-terminal YTH domain greatly participated in targeting RNA backbone and residues W432 and W486 within the hydrophobic pocket. fifa 21 pc iso file download